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Interrelation between the effects of ethanol and thyroid hormones on gluconeogenesis from alanine in perfused rat liver

Singh, S.P.; Snyder, A.K.

Journal of Laboratory and Clinical Medicine 99(5): 746-753

1982

ISSN/ISBN: 0022-2143
PMID: 7069271
Document Number: 196658
Ethanol and thyroid hormones are factors that can alter hepatic gluconeogenesis. The interrelation between the influence of ethanol and T4 to 3PGA and of Ala were increased as compared to normal rat liver. Ethanol attenuated T4 effects on Ala uptake and on pyruvate conversion to PEP. NADH produced by ethanol oxidation enhanced 3PGA conversion to DHAP in T4-treated and normal rat liver. Despite these effects of ethanol on the gluconeogenic pathway, T4 stimulation of the rate of gluconeogenesis was not affected by ethanol. With an adequate supply of Ala as substrate, ethanol stimulated gluconeogenesis in normal rat liver but had no affect on an already enhanced gluconeogenesis in thyrotoxic rat liver.

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