Thyroid hormones and phospholipase activity in rat liver mitochondria
Marzoev, A.I.; Andriushchenko, A.P.; Vladimirov, I.A.
Biulleten' Eksperimental'noi Biologii i Meditsiny 96(12): 45-46
1983
ISSN/ISBN: 0365-9615 PMID: 6661546 Document Number: 204940
The rate of the hydrolysis of mitochondrial phospholipids isolated from the liver of rats given excess amount of thyroid hormones for a long time was higher than in normal animals. Activation of this process determined by endogenous phospholipase of mitochondria could be also observed in liver mitochondria isolated 2 days after a single injection of L-thyroxine into rats. It is assumed that the hyperthyrosis-induced acceleration of lipid peroxidation in these organelles might be one of the reasons for activation of endogenous phospholipase of mitochondria.