Psoriasis therapy with the aromatic retinoid Ro 10-9359 (Tigason)
Sönnichsen, N.; Harnack, K.; Barth, J.; Heilmann, S.; Jäger, K.; Metz, D.; Schiller, F.
Zeitschrift für Hautkrankheiten 58(17): 1257-1267
1983
ISSN/ISBN: 0301-0481 PMID: 6636927 Document Number: 204939
At three University Departments of Dermatology (Berlin, Leipzig, Erfurt) of the GRD, 63 psoriatics (46 men, 17 women) were treated with aromatic retinoid Ro 10-9359 (Tigason) up to a maximum of 84 weeks. In 34 of these cases, photochemotherapy was additionally applied. This combination resulted in a more rapid healing than Tigason alone. The average initial dose amounted to 1 mg per kg body weight. Only in cases of psoriatic erythroderma, the treatment started with a daily rate of 25 mg Tigason. The maintenance dose came to 50 to 25 mg daily. On account of deterioration of the cutaneous condition and/or heavy itching, the treatment had to be discontinued in 4 cases. Side effects as cheilitis, rhagades, loss of hair, and onycholysis disappeared after reduction of the dose. Our study confirmed the good therapeutical effect of Tigason with the various forms of psoriasis.