Epidermic chalone receptors in psoriasis treated with retinoid:Ro 10-9359
Vignale, R.A.; Lasalvia, E.; Espasandín, J.; Borras, A.
Medicina Cutanea Ibero-Latino-Americana 11(4): 241-246
1983
ISSN/ISBN: 0210-5187 PMID: 6314070 Document Number: 215561
The epidermic chalone receptor of skin with lesion and without lesion are studied on 20 patients with active psoriasis. The testlest were performed before and two month after oral treatment with RO 10-9359. Roche. The results show significant variation with an increased a the number of receptors after treatment. As these receptors are in the cell membrane, the authors consider that RO 10-9359 action in on the membrane and its surrounding, making in possible to the epithelial cell to begin its autoregulation, autocontrol and differentiation when the specific activity of the chalones become normal.