Ethanol-induced focal cell necrosis via microcirculatory disturbance in the perfused rat liver
Oshita, M.; Sato, N.; Yoshihara, H.; Takei, Y.; Kashio, S.; Hijioka, T.; Fukui, H.; Goto, M.; Matsunaga, T.; Okumura, S.
Alcohol and Alcoholism . Suppl 1: 317-320
1991
ISSN/ISBN: 1358-6173 PMID: 1845554 Document Number: 385219
In the perfused rat liver, infusion of ethanol induced an initial increase in portal pressure which is an indicator of vasoconstriction and a subsequent increase in lactic dehydrogenase (LDH) release, which is an indicator of cell damage in a dose-dependent fashion. Simultaneous infusion of sodium nitroprusside, a potent vasodilator, (100 microM) inhibited the increases in portal pressure and LDH release. Focal hepatocellular necrosis evidenced by trypan-blue stained cell nuclei were localized in midzonal and pericentral area of the liver lobules at 60 min after ethanol load. These ethanol-induced microcirculatory disturbance might be involved in the pathogenesis of alcoholic liver disease.