Therapeutic effectiveness of cystamine and cysteine to reduce liver cell necrosis induced by several hepatotoxins
de Ferreyra, E.C.; de Fenos, O.M.; Bernacchi, A.S.; de Castro, C.R.; Castro, J.A.
Toxicology and Applied Pharmacology 48(2): 221-228
1979
ISSN/ISBN: 0041-008X PMID: 473171 Document Number: 140205
Cystamine or cysteine administration to rats receiving dimethylnitrosamine, thioacetamide or bromobenzene 3, 6 or 12 h before, partially prevented the liver necrosis produced by these substances at 24 h. Both chemicals were unable to prevent the necrosis induced by allyl alcohol and aflatoxin B1. Since at either 6 h (dimethylnitrosamine) or 12 h (bromobenzene and thioacetamide), most of activation of the agents and the subsequent interaction with cell constituents already occur, cystamine or cysteine apparently protect because they alter cellular response to the hepatotoxins. The possible application of these chemicals in therapeutics is suggested.