Clinical evaluation of quinacrine pellets for chemical female sterilization
Agoestina, T.; Kusuma, I.
Advances in Contraception the Official Journal of the Society for the Advancement of Contraception 8(2): 141-151
1992
ISSN/ISBN: 0267-4874 PMID: 1519496 DOI: 10.1007/bf01849751Document Number: 320617
Under the auspices of the Coordinating Board of Indonesian Fertility Research (BKS PENFIN), a clinical trial was undertaken to examine the safety and effectiveness of the quinacrine pellet method for nonsurgical female sterilization. One hundred women were selected to receive 3 monthly insertions of 250 mg of quinacrine and were followed up at 1, 3, 6 and 12 months after the third insertion. Socioeconomic data and complaints and menstrual patterns at each insertion and every follow-up visit were recorded, as were all failures. The life-table failure rate was determined to be 3.1. The continuation rate in this study was 90% at 1 year. Just over one-fifth of the women had amennorhea by the third insertion, but most returned to normal by 1 year, and it appears that this amenorrhea was transient in nature. The method proved to be safe and effective, suggesting that larger clinical trials are in order.
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