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Effect of heparin on fibrinogen formation during experimental toxic syndrome of disseminated intravascular coagulation

Barkagan, Z.S.; Momot, A.P.; Glazunova, G.A.; Taranina, T.S.; Koltakova, S.I.

Ukrainskii Biokhimicheskii Zhurnal 60(1): 23-29

1988

ISSN/ISBN: 0201-8470
PMID: 3363673
Document Number: 320616
The formation of circulation components of fibrinogen pool in toxigenic syndrome of disseminated intravascular blood coagulation (DBC-syndrome) caused by the Vipera lebetina turanica venom has been examined by the gel-filtration method. Simultaneously it has been studied what components of fibrinogen pool are removed in paracoagulation tests and with addition of the coagulating enzymes (thrombin, reptilase and the Echis multisguamatus venom) to the plasma. The preliminary heparinization of animals poisoned by Vipera lebetina turanica venom was found to prevent the fibrinogen formation mainly at the fibrin-monomer formation stage. Besides, the effect of polymerization inhibition was revealed in the plasma of such animals.

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