Results of a randomized, double blind prospective study of intravesical chemoprophylaxis with 2 drugs: adriamycin and mitomycin; and 2 ways of initiating the instillations: early and late. Effect on recurrence and progression
Iborra Juan, I.; Ricos Torrent, J.V.; Monrós Lliso, J.L.; Dumont Martínez, R.; Casanova Ramón-Borja, J.; Solsona Narbón, E.
Archivos Espanoles de Urologia 45(10): 1001-1007
1992
ISSN/ISBN: 0004-0614 PMID: 1294028 Document Number: 397337
The results of a double blind prospective study comparing the chemoprophylactic effects of adriamycin and mitomycin C and two modes of instillation (early: 6 hours following transurethral resection; late: 7-14 days later) for superficial carcinoma of the bladder are presented herein. Since the minimum follow up is over 5 years, the effects on tumor progression and mortality achieved by each of the 4 arms of the protocol were also evaluated. Concerning tumor recurrence, early instillation of mitomycin and overall early instillation therapy achieved significantly better results (p < 0.01). No differences, however, were observed relative to tumor progression or mortality.