Effect of nilvadipine on nifedipine-induced edema of the lower leg. Results of a double-blind randomized comparative study
Vollmuth, M.; Schmitt, W.
Fortschritte der Medizin 112(18): 266-270
1994
ISSN/ISBN: 0015-8178 PMID: 8088691 Document Number: 424740
Evaluation of the effects of nilvadipine on nifedipine-induced lower-leg edema. multicenter, randomized, double-blind study. 61 outpatients suffering from essential hypertension with diastolic blood pressure adjusted to < or = 95 mmHg by nifedipine, and simultaneous lower-leg edema. First phase: wash-out--placebo b.i.d.; Second phase: slow-release nifedipine 20 mg b.i.d.; Third phase: slow-release nifedipine 20 mg b.i.d. or nilvadipine 8 mg (mornings) and placebo (evenings). Lower leg volume, blood pressure, heart rate, weight, laboratory investigations, undesired effects, assessment of effectiveness and tolerability by the physician, subjective patient assessment. Patients treated with nilvadipine immediately following nifedipine therapy showed a significant decrease in lower-leg volume as compared with those continuing to receive nifedipine. In about half of the patients receiving nilvadipine, nifedipine-induced lower-leg edema disappeared completely. No differences were seen between the two substances in terms of effectiveness or tolerability.