4-Methyltrityl (Mtt) : a new protecting group for the side chain protection of Asn and Gln in solid-phase peptide synthesis
Sax, B.; Dick, F.; Tanner, R.; Gosteli, J.
Peptide Research 5(4): 245-246
1992
ISSN/ISBN: 1040-5704 PMID: 1421811 Document Number: 394631
The trityl group was recently introduced for the protection of the side chain carboxamide function of asparagine and glutamine. The 4-methyltrityl (Mtt) group, a structural modification of trityl, is presented here and allows more rapid cleavage from the protected peptides. Procedures for the introduction of the group and comparative cleavage reactions are also presented.
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