Phenotypic and genotypic analysis of acute leukemia--current status of lineage specific classification
Kawa, K.; Hara, J.
Nihon Rinsho. Japanese Journal of Clinical Medicine 50(6): 1315-1320
1992
ISSN/ISBN: 0047-1852 PMID: 1518151 Document Number: 392497
More detailed identification and understanding of the heterogeneity of leukemias using a broad panel of markers seems to be essential for the successful design of more sophisticated and effective treatments. Based on the FAB system, immunological phenotypes using a panel of monoclonal antibodies, and rearrangements of immunoglobulin and T-cell receptor genes, acute leukemia can be divided into six subtypes such as B-lineage, T-lineage, AML, NK-lineage, AUL and mixed lineage leukemia. The definition of B-lineage and T-lineage cells, a new classification for mixed lineage leukemia, incidence of dual rearrangements and their clinical significance are discussed.