Phenotypic and genotypic heterogeneity in large granular lymphocyte expansion
Loiseau, P.; Divine, M.; Le Paslier, D.; Marolleau, J.P.; Farcet, J.P.; Flandrin, G.; Cohen, D.; Degos, L.; Sigaux, F.; Reyes, F.
Leukemia 1(3): 205-209
1987
ISSN/ISBN: 0887-6924 PMID: 3669743 Document Number: 292819
The cellular heterogeneity of large granular lymphocyte expansions has been illustrated by the phenotypic and genotypic findings in five patients. In one patient whose circulating cells were CD2+, CD3-, CD5-, CD7+, CD8-, CD11+, Leu7+, CD16+, and displayed strong natural killer activity, no rearrangement of the T cell receptor .beta.-chain gene and T cell rearranging gene .gamma. was detected. The four other patients presented with neutropenia without overt lymphocytosis. In these patients the circulating lymphocytes expressed a predominant T cell phenotype CD2+, CD3+, CD5+, CD7+, CD8+, Leu7+. In three of them the presence of a T cell clone was demonstrated on the basis of a unique pattern of rearrangement of the T cell receptor .beta.-chain genes.