Mechanism of the relaxant response of the rat duodenum to bradykinin
Feres, T.; Funari, C.C.; Paiva, A.C.; Paiva, T.B.
Agents and Actions. Supplements 38: 398-405
1992
ISSN/ISBN: 0379-0363 PMID: 1334340 Document Number: 392016
Bradykinin (BK) did not increase cyclic AMP production in cultured rat duodenum smooth muscle cells. Its relaxant effect on the tissue was inhibited by apamin and potentiated by phorbol dibutyrate (PDBU). PDBU also caused a relaxation which was inhibited by apamin. BK's relaxant effect, and its potentiation by PDBU, are due to activation of Ca(2+)-dependent K+ channels.
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