Comparative study of cardiocirculatory response and respiratory reflex to the injection of bradykinin, inorganic phosphates and prostaglandins into the femoral artery
Baldoni, F.; Tallarida, G.; Peruzzi, G.; Raimondi, G.; Massaro, M.; Sangiorgi, M.
Bollettino della Societa Italiana di Biologia Sperimentale 57(16): 1680-1686
1981
ISSN/ISBN: 0037-8771 PMID: 7306410 Document Number: 171098
In 15 anesthetized rabbits the reflex changes in arterial pressure, heart rate and respiratory rate in response to injections of bradykinin inorganic phosphate and prostaglandins into femoral artery have been studied. Intraarterial injection of bradykinin produced a reflex fall in arterial pressure, bradycardia and tachypnea. The latency of response ranged from 6 to 7 sec. The threshold dose was about 50 ng. This effect was accompanied by a consistent increase in the afferent discharge in the saphenus nerve. Isotonic mixtures of Na2HPO4 and NaH2PO4 at pH 7, PGE1, PGE2, and PGA, when injected into femoral artery even in high doses, failed to produce any significant cardiocirculatory or respiratory reflex responses. Infusion of PGE1 (1 ug/min) into femoral artery, although inactive by itself, enhanced the reflex effect of bradykinin.