Mechanism of action of dantrolene sodium, a peripherally acting muscle relaxant
Endo, M.; Yagi, S.
Electroencephalography and Clinical Neurophysiology. Suppl 36: 216-220
1982
ISSN/ISBN: 0424-8155 PMID: 6962016 Document Number: 194781
The mechanism of action of dantrolene sodium, a peripherally acting muscle relaxant, is reviewed. It does not alter action potentials or responses of the contractile proteins to Ca. The amount of Ca acting on the contractile proteins during twitch must, therefore, be reduced, but since Ca uptake by the SR is not altered, Ca release from the SR must be reduced by the drug. Other characteristics of this drug and their clinical implications are discussed.