The effect of sodium dantrolene on the detrusor urinae muscle of the bladder isolated from guinea pigs
Lograno, M.D.; Conte-Camerino, D.; De Filippis, F.
Bollettino della Societa Italiana di Biologia Sperimentale 55(5): 484-488
1979
ISSN/ISBN: 0037-8771 PMID: 553606 Document Number: 143111
The effects of dantrolene sodium were evaluated in vitro using the guinea pig detrusor muscle preparation. Dantrolene reversibly decreased the strength of the responses of the detrusor to acetylcholine and histamine. The drug seems to depress the detrusor muscle of the bladder as it does others smooth muscles.
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