Comparative effects of indomethacin and proglumetacin on 6-oxo-PGF1 alpha released ex vivo by rat gastric mucosa
Conti, P.; Alesse, E.; Cifone, M.G.
International Journal of Tissue Reactions 8(1): 31-34
1986
ISSN/ISBN: 0250-0868 PMID: 3512465 Document Number: 3910
The authors compare the effect of indomethacin and proglumetacin on the production of prostacyclin in the rat gastric mucosa, and investigate the potential ulcerogenic effect elicited by the two drugs. The results show that indomethacin and proglumetacin, at doses giving similar inhibition of gastric-protacyclin synthesis, drastically differ in their gastric ulcerogenic effects.
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