The ultrastructural characteristics of the changes in sections of the rat brain under piracetam exposure
Makliakov, I.S.; Karkishchenko, N.N.; Bardakhch'ian, E.A.; Kharlanova, N.G.
Eksperimental'naia i Klinicheskaia Farmakologiia 55(6): 9-12
1992
ISSN/ISBN: 0869-2092 PMID: 1305888 Document Number: 388413
Rat experiments have shown that intraperitoneal piracetam leads to formation of abundant coated vesicles in the neurons of the sensomotor cortex, hippocampus, and central gray matter. Concurrently, subsuperficial cisterns form under the plasmalemma of nerve cells. The interneuronal contacts are characterized by long-term excitation without destructive changes in synapses. It is suggested that piracetam is able to increase the number of synapses in some brain regions at the expense of sprouting.