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The effect of emotional stress on carboxypeptidase H activity in sections of the rat brain with varying sensitivity to it

Gengin, M.T.; Vernigora, A.N.; Nikishin, N.N.; Kerimov, V.Iu.

Voprosy Meditsinskoi Khimii 41(4): 8-9

1995

ISSN/ISBN: 0042-8809
PMID: 8571594
Document Number: 447248
The activity of carboxypeptidase H involved in metabolism of neuropeptides was studied in rats resistant and predisposed to emotional stress under normal and stress conditions. The enzymatic activity was higher in the striatum and hypothalamus of the rats predisposed to stress than that of stress-resistant animals. Emotional stress resulted in activation of the enzyme in these both groups of animals, while the dynamics of the enzyme activity depended on the resistance of animals to stress and the poststress interval. There was a correlation between the activity of carboxypeptidase H and the content of neuropeptides in animals with varying stress-resistance.

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