The ionic regulation of the receptor binding of S35-tert-butylbicyclophosphorothionate by brain membranes in inbred mice with different emotional stress reactions
Blednov, I.A.; Nagovitsina, I.A.; Gordeĭ, M.L.; Seredenin, S.B.
Biulleten' Eksperimental'noi Biologii i Meditsiny 114(8): 201-204
1992
ISSN/ISBN: 0365-9615 PMID: 1334730 Document Number: 400532
Comparative study of effects of ionic concentrations on [35S]-TBPS binding was performed on brain membranes of inbred mice. It was shown that low concentrations of LiCl (less than 100 mM) were more stimulatory effective in Balb/c (C) mice than in C57Bl/6 (B6) mice. On the contrary, stimulatory activity of NaNO (less than 100 mM) was more pronounced in B6 mice. The revealed line of activity of cations (Li+ > K+ > Na+) and anions (Cl- > or = Br- > I-) makes it possible to doubt interpretation of the obtained data only as affinity of the ions to their channels. We suggest the role of ions as modifiers of surface charge of neuronal membrane, that may be the main cause of the revealed interstrain differences.