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The influence of piracetam on the cyclic adenosine monophosphate (cAMP) concentration in the brain and colon of guinea pigs

Weth, G.

Arzneimittel-Forschung 33(6): 812-814

1983

ISSN/ISBN: 0004-4172
PMID: 6311225
Document Number: 214864
During investigations of 2-oxy-pyrrolidine-acetamide (piracetam, Nootrop) the influence on the cyclic adenosine monophosphate (cAMP) level was measured. 20 guinea pigs (inbred albinos) were used for the investigations. 6 animals served as a control group, 14 animals were treated daily for 16 days with 35 mg piracetam/kg b.w. The cAMP concentration was determined in the frontal brain and intestine. The animals treated 16 days with piracetam showed an increase of cAMP in the frontal brain of 134% compared with untreated animals. In the intestinal tissue, the difference between the control group and the piracetam-treated animals ranged around 84%.

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