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The specificity of the genotoxic action of carcinogenic aromatic compounds on Drosophila mus mutants

Shpigel'man, V.S.; Fuks, S.I.; Safaev, R.D.; Belitskiĭ, G.A.

Biulleten' Eksperimental'noi Biologii i Meditsiny 112(11): 521-523

1991

ISSN/ISBN: 0365-9615
PMID: 1810494
Document Number: 387923
Hypersensitivity to the toxic effect of benzo(a)pyrene (B(a)P) was determined in homozygous larvae of two D. melanogaster mus strains (mus 208B2 and mus210). The two others (mus205B1 and mus208B1) were found to be less sensitive and the parent strain was resistant. The lack of correlation between the sensitivity in larvae and the activity of aryl hydrocarbon hydroxylase in S15 fractions from adult flies whole body homogenates of the same strains was demonstrated. The hypertoxic effect of B(a)P and 2-acethylaminofluorene in strain mus210 seems to be rather specific because noncarcinogenic pyrene, benzo(e)pyrene and fluorene did not affect the survival of this most sensitive strain. Perspectives of the strain mus210 use for the environmental genotoxic pollutants screening were discussed.

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Korosteleva, T.A.; Potapenkova, L.S. 1978: Comparative study of the carcinogenic activity and immunological specificity of aminoazo compounds Gigiena Truda i Professional'nye Zabolevaniya (5): 24-27
Neumann, H.G.; Metzler, M.; Brachmann, I.; Thomas, C. 1970: The relevance of chemico-biological interactions for the toxic and carcinogenic effects of aromatic amines. I. Carcinogenic activity of some 4-aminostilbene and 4-aminobibenzyl-derivatives Zeitschrift für Krebsforschung 74(2): 200-206
Druckrey, H.; Preussmann, R.; Nashed, N.; Ivankovic, S. 1966: Carcinogenic alkylating substances. I. Dimethylsulfate, carcinogenic action in rats and probable cause of occupational cancer Zeitschrift für Krebsforschung 68(1): 103-111
Glavin, O.A.; Mikhailenko, P.M.; Zaletok, S.P.; Gulua, L. 2008: Effects of green and black tea biocomposites on endogenous synthesis, metabolism and genotoxic effect of carcinogenic N-nitrosodimethylamine Experimental Oncology 30(4): 306-314
Vachálková, A.; Benesová, M.; Bahna, L. 1982: Electrochemical properties of polycyclic compounds studied by the polarographic method in anhydrous systems. VIII. the influence of proton-donor on reduction of carcinogenic nitrogen compounds in dimethylformamide Neoplasma 29(2): 161-167
Aslanian, M.M.; Smirnova, V.A. 1981: Analysis of the mutations induced by alkylating compounds in Drosophila sperm. II. the nature of the chemically induced unstable locus states in Drosophila melanogaster Genetika 17(4): 684-693
Sugimura, T.; Nagao, M. 1981: Carcinogenic, Mutagenic, and Comutagenic Aromatic Amines in Human Foods National Cancer Institute Monograph 58: 27-33
Pentiuk, A.A.; Durnev, A.D.; Matviĭchuk, N.V.; Gutsol, V.I.; Iavorskiĭ, A.N.; Shcherbaniuk, V.V.; Seredenin, S.B. 1995: Vitamin a and enzyme systems of metabolic activation of genotoxic compounds Vestnik Rossiiskoi Akademii Meditsinskikh Nauk 1: 3-9
Gross, G.A.; Grüter, A. 1992: Quantitation of mutagenic/carcinogenic heterocyclic aromatic amines in food products Journal of Chromatography 592(1-2): 271-278
Pashin, I.V.; Bakhitova, L.M. 1980: Factors that enhance the carcinogenic and mutagenic activity of polycyclic aromatic hydrocarbons Gigiena i Sanitariia 7: 54-56
Indulski, J.A.; Krajewska, B.; Lutz, W. 1992: Acetylation phenotype as a biomarker of sensitivity to the carcinogenic effect of aromatic amines Medycyna Pracy 43(5): 427-435
Nguyen, T.D.; Boyd, J.B.; Green, M.M. 1979: Sensitivity of drosophila mutants to chemical carcinogens Mutation Research 63(1): 67-77
Parádi, E.; Szidonya, J.; Faludi, B. 1971: The fitness of CyL and freckled (Frd) mutants of Drosophila melanogaster Acta Biologica Academiae Scientiarum Hungaricae 22(4): 457-466
Shabad, L.M. 1980: Circulation of carcinogenic polycyclic aromatic hydrocarbons in the human environment and cancer prevention Journal of the National Cancer Institute 64(3): 405-410
Pott, F.; Werner, W. 1983: Analysis and evaluation of carcinogenic polycyclic aromatic hydrocarbons from the air hygiene and toxicology viewpoint Zeitschrift für die Gesamte Hygiene und ihre Grenzgebiete 29(9): 505-507
Guillén, A.; Jallon, J.M.; Fehrentz, J.A.; Pantaloni, C.; Bockaert, J.; Homburger, V. 1990: A Go-like protein in Drosophila melanogaster and its expression in memory mutants EMBO Journal 9(5): 1449-1455
Dybing, E.; Von Bahr, C.; Aune, T.; Glaumann, H.; Levitt, D.S.; Thorgeirsson, S.S. 1979: In vitro metabolism and activation of carcinogenic aromatic amines by subcellular fractions of human liver Cancer Research 39(10): 4206-4211
Bragina, I.V.; Kamyshev, N.G. 2001: Comparative study of four P-insertional memory-deficient Drosophila mutants Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 87(6): 801-809
Shcherbata, G.R.; Matiĭtsiv, N.P.; Chernik, I.I.; Maksimiv, D.V. 2004: Chemically induced Drosophila melanogaster mutants with changes in brain structure Genetika 40(9): 1280-1285
Levchuk, A.A.; Pal'mina, N.P.; Raushenbakh, M.O. 1987: Effect of the carcinogenic metabolites of aromatic amino acids on oxidative processes in lipids in vitro and in vivo Biulleten' Eksperimental'noi Biologii i Meditsiny 104(7): 77-79