Effect of the carcinogenic metabolites of aromatic amino acids on oxidative processes in lipids in vitro and in vivo
Levchuk, A.A.; Pal'mina, N.P.; Raushenbakh, M.O.
Biulleten' Eksperimental'noi Biologii i Meditsiny 104(7): 77-79
1987
ISSN/ISBN: 0365-9615 PMID: 2441774 Document Number: 289147
A comparative study of the effect produced by endogenous carcinogens (p-hydroxyphenyllactic and 5-methoxyindole-3-acetic acids) and their non-cancerogenic analogues on lipid peroxidation in vitro and in vivo was performed. It has been found that cancerogenic tyrosine and serotonin metabolites, unlike their non-cancerogenic analogues, increase lipid peroxidation in vitro. In vivo, cancerogenic tyrosine metabolite--p-hydroxyphenyllactic acid--is capable both of increasing and decreasing antioxidative lipid activity in the animal liver.