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Chemically induced Drosophila melanogaster mutants with changes in brain structure

Shcherbata, G.R.; Matiĭtsiv, N.P.; Chernik, I.I.; Maksimiv, D.V.

Genetika 40(9): 1280-1285

2004

ISSN/ISBN: 0016-6758
PMID: 15559158
Document Number: 567942
Neurodegenerative human diseases are caused by nerve cell death and anatomical changes in some brain regions. Molecular genetic studies of Drosophila showed that this organism can serve as a valuable test-system for conserved mechanisms underlying human nervous system disorders. Analysis of brain functions is possible when the mutants with disturbed functions are available. In this study, we have developed a unique collection of Drosophila melanogaster mutants with morphological and neurodegenerative changes in brain structure, which were induced by chemical mutagens.

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