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Complex influence of pharmacological agents on degenerative processes in brain of Drosophila melanogaster mutants

Radysh, V.V.; Maksymiv, D.V.; Makarenko, A.N.

Eksperimental'naia i Klinicheskaia Farmakologiia 69(5): 16-19

2006

ISSN/ISBN: 0869-2092
PMID: 17153959
Document Number: 602523
A scheme of complex administration of drugs in the order neuroprotector + neuroactivator + neuroretarder for the treatment of neurodegenerative processes in the brain has been elaborated and tested on a model object representing neurodegenerative mutants of Drosophila melanogaster. The appearance of changes in the brain was delayed when drugs were used separately: donepezil hydrochloride (arisept), 10 - 11 days, epinephrine and nimodipine, I - 2 days. The treatment of flies with the same drugs in the order arisept + epinephrine + nimodipine leads to the complete regeneration of D. melanogaster brain tissue to within 15 days of imago life.

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