Effect of centbucridine & lignocaine on biochemical changes in isoproterenol induced ischemia in rats
Dikshit, M.; Srimal, R.C.
Indian Journal of Medical Research 94: 307-311
1991
ISSN/ISBN: 0019-5340 PMID: 1959964 Document Number: 386324
Effect of lignocaine and centbucridine against isoproterenol-induced biochemical changes was studied in the rat. Isoproterenol (40mg/kg twice) increased the heart weight, level of malondialdehyde (MDA) and activity of acid phosphatase, but decreased the myocardia phospholipid content at 48 h. In addition, increase in plasma triglyceride, cholesterol, MDA and creatine phosphokinase activity was observed. Pretreatment of the animals with lignocaine (10 mg/kg) or centbucridine (1, 3, and 10 mg/kg) protected the animals against these biochemical changes. However, increase in heart weight consequent to isoproterenol treatment could not be prevented. Total protection against creatine phosphokinase release in the blood was also not observed. The results suggest that the two drugs inhibit lipolysis. They may also inhibit phospholipases leading to potection against ischemia-induced changes in the rat.