Dynamics of the change in Na, K-ATPase activity during the development of isoproterenol-induced myocardial necrosis in rats
Mel'nik, V.I.; Glebov, R.N.
Biulleten' Eksperimental'noi Biologii i Meditsiny 98(8): 184-186
1984
ISSN/ISBN: 0365-9615 PMID: 6147166 Document Number: 237652
Na, K-ATPase activity of heart tissue homogenates was found to be depressed 6 and 24 h after the last injection of isoproterenol to rats (100 mg/kg s. c. daily for 2 consecutive days) whereas after 1 h it was essentially unchanged. The extent of the reduction in the enzyme activity was virtually the same both 6 and 24 h after myocardial necrosis induction (18 and 19%, respectively). The time-course of changes in the activity of the sarcolemmal marker enzyme was compared to the reported data on the increased sarcolemmal permeability in isoproterenol-induced myocardial necrosis.