Alterations in some lipid components and Ca2+ ATPase activity in brain of rats fed an atherogenic diet
Oner, P.; Bekpinar, S.; Oz, B.
Research Communications in Chemical Pathology and Pharmacology 72(3): 337-345
1991
ISSN/ISBN: 0034-5164 PMID: 1835114 Document Number: 385975
Male Wistar rats were fed on an atherogenic diet (containing cholesterol and cholic acid 20 and 5 g/kg diet, respectively), for 4 months. Total cholesterol and triacylglycerol concentrations were increased significantly in both serum and brain, while the phospholipid concentration was decreased in both, compared with valves in controls fed on a stock diet. The distribution of serum cholesterol between high-density and low-density lipoprotein (HDL and LDL, respectively) was altered when compared with control rats, and there was a decrement in HDL-cholesterol and a pronounced increment in LDL-cholesterol in rats on the atherogenic diet. The atherogenic diet resulted in about 50% reduction in brain Ca2+ ATPase activity. It is concluded that alterations in ion transport and neurotransmitter release may be expected due to pronounced inhibition of brain Ca2+ ATPase activity in rats fed on an atherogenic diet.