Insular modifications in glycerophosphate dehydrogenase in diabetes
Malaisse, W.J.; Rasschaert, J.
Bulletin et Memoires de l'Academie Royale de Medecine de Belgique 146(1-2) 106-110; Discussion: 111-112
1991
ISSN/ISBN: 0377-8231 PMID: 1933065 Document Number: 385800
In the model of non-insulin-dependent diabetes found in adult rats injected with streptozotocin during the neonatal period, the activity of the mitochondrial glycerophosphate dehydrogenase is severely reduced in pancreatic islets. This coincides with a decreased contribution of aerobic to total glycolysis in intact islets and could account for the preferential impairment of the insulin secretory response to glucose.
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