Blood platelet serotonin following enterectomy in rats
Osim, E.E.; Wyllie, J.H.
Acta Physiologica Hungarica 78(2): 173-179
1991
ISSN/ISBN: 0231-424X PMID: 1808983 Document Number: 382009
The role of the intestine as a source of platelet serotonin was investigated. Radioactive serotonin precursor. 5-Hydroxytryptophan was injected into enterectomised and sham-operated rats. Blood samples were taken at time intervals and serotonin uptake was estimated by radioactive counting. Soon (1-2 hrs) after surgery and under sodium pentobarbital anaesthesia, platelet 5HT activity was higher in enterectomised rats than in controls. The intestine may not be the major source of platelet serotonin.