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Losartan does not influence the blood platelet aggregation in normotensive rats

Chabielska, E.; Pawlak, R.; Buczko, W.

Acta Physiologica Hungarica 84(3): 271-272

1996

ISSN/ISBN: 0231-424X
PMID: 9219602
Document Number: 464809
Platelet aggregation was studied in PRP upon stimulation with ADP and collagen in normotensive rats treated with losartan (10 mg/kg). The acute and subchronic (5 days) losartan administration did not change the aggregating response of rat platelets. Similarly, in vitro study aggregation of platelets remained unaltered following incubation with losartan and its active metabolite EXP3174. In this study we presented the lack of influence of losartan and its main metabolite on rat platelet aggregation in normotensive rats.

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