Bacterial resistance to norfloxacin and other newer quinolones: pattern and prospects
Nalin, D.R.
European Journal of Cancer and Clinical Oncology 24(Suppl 1): S55-S61
1988
ISSN/ISBN: 0277-5379 PMID: 3280327 Document Number: 3812
The rapid spread of microbial resistance which quickly vitiated the therapeutic utility of nalidixic acid and other first generation quinolone antibiotics contrasts strikingly with the low incidence of clinically significant resistance emerging during the first years of widening clinical use of norfloxacin and other broad spectrum second generation quinolones. This difference is best understood in relation to the mechanisms of quinolone efficacy and of - microbial resistance, and the spectrum of microbial susceptibility and targeted infection sites in relation to antimicrobial pharmacokinetics and distribution in relevant body tissues and fluids. Such aspects also provide a basis for analysis of future prospects for continued susceptibility of pathogens within the activity spectrum of norfloxacin.
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