BRL 43694, a new 5HT3 receptor antagonist, prevents cisplatin-induced emesis in dogs
Bhandari, P.; Gupta, Y.K.; Seth, S.D.
Methods and Findings in Experimental and Clinical Pharmacology 11(5): 361-363
1989
ISSN/ISBN: 0379-0355 PMID: 2547129 Document Number: 3811
This study confirms that BRL 43694 affords significant protection against cisplatin-induced emesis in dogs. Though there was a dramatic decrease in the mean number of emetic episodes per dog, complete protection was observed in only 40% of the animals tested. This, we think, is cause for concern. BRL 43694 did not provide any protection to apomorphine-induced emesis, which suggests that in its anti-emetic action it does not affect the motor component of the emetic reflex.
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