Synthesis and biological activity of some new 5-hydrothiazolo[4,3-b]-1,3,4-oxa (thia) diazoles and 5-hydrothiazolo[3,4-b]-1,2,4-triazoles containing 1,2,3-selena (thia) diazole moiety
El-Sayed Bayoumy, B.
Acta Poloniae Pharmaceutica 48(1-2): 13-18
1991
ISSN/ISBN: 0001-6837 PMID: 1669421 Document Number: 381158
P-Acetylphenyl thiosemicarbazide (I) was reacted with different aldehydes yielding the corresponding semicarbazones II. Addition condensation of thioglycolic acid with compounds II gave 4-thiazolidinones III. Reaction of compounds III with conc. H2SO4, KI/I2-NaOH and NaOH afforded the cyclized products (IV-VI). Compounds (IV-VI) reacted with semicarbazide to give the corresponding semicarbazones (VII-IX) which either were oxidized with selenium dioxide or thionyl chloride to give 1,2,3-selenadiazoles (X-XII) and 1,2,3-thiadiazoles (XIII-XV) respectively. Some of the prepared compounds were tested against some strains of bacteria.