Chronic electroconvulsive treatment counteracts cortical beta-adrenoceptor upregulation induced by morphine abstinence
Vetulani, J.; Antkiewicz-Michaluk, L.; Michaluk, J.; Rokosz-Pelc, A.
Polish Journal of Pharmacology and Pharmacy 43(2): 89-93
1991
ISSN/ISBN: 0301-0244 PMID: 1658759 Document Number: 380016
Morphine treatment (20 mg/kg for 7 consecutive days) did not affect the density of [3H]dihydroalprenolol ([3H]DHA) binding sites in the cortical membranes of the rat, but during naloxone-precipitated abstinence syndrome the density of these sites increased. Electroconvulsive treatment for 6 days, which by itself decreased the density of [3H]DHA binding sites, prevented the increase.
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