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Differential effect of cannabinol and cannabidiol on THC-induced responses during abstinence in morphine-dependent rats

Hine, B.; Torrelio, M.; Gershon, S.

Research Communications in Chemical Pathology and Pharmacology 12(1): 185-188

1975

ISSN/ISBN: 0034-5164
PMID: 1237925
Document Number: 90493
The same dose of cannabinol (CBN) or cannabidiol (CBD) further increased the attenuation of precipitated abstinence signs observed in morphine-dependent rats that also received an acute dose of delta 9-THC. By contrast, rotational behavior (turning), which is observed concomitantly in THC-treated rats during morphine abstinence, was not increased by CBN, but was potentiated by CBD. These data illustrate differences between psychoinactive cannabinoids in their interaction with delta 9-THC that might be relevant to possible clinical use of Cannabis in narcotic detoxification.

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