The biodisposition of paracetamol. I. the kinetics of disintegration of some dosage forms
Abebe, A.; Chulia, D.; Verain, A.
Pharmaceutica Acta Helvetiae 66(2): 56-59
1991
ISSN/ISBN: 0031-6865 PMID: 1758894 Document Number: 374466
The in vitro properties of twelve brands of paracetamol (nine tablets and three capsules), commercialized in France, are studied. Among the brands tested (tablets), Latepyrine and Gynospasmine are characterized by faster and Panasorb by slower dissolution rate. Total time of dissolution varies between 7 and 60 min. In some brands, paracetamol is liberated from the surface of the disintegrated particles and in others the active principle is released by progressive erosion. The presence of a surface active agent enhances liquid penetration in the case of capsules.