Spectrophotometric determination of diltiazem in dosage forms
Zivanov-Stakić, D.; Agbaba, D.; Vladimirov, S.; Cirić, L.J.
Farmaco 47(3): 393-396
1992
ISSN/ISBN: 0014-827X PMID: 1503602 Document Number: 398425
A simple and reproducible method for determination of diltiazem in bulk and in dosage forms is presented. The method is based on formation of hydroxamic acid, which reacts with iron (III), forming a complex with a maximum absorption at 525 nm. Assay procedure for diltiazem dosage form requires thin-layer chromatographic separation prior to colorimetric analysis.
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