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Biological effect of human erythropoietin in transgenic mice

Mudrik, N.N.; Eshkind, L.G.; Manakova, T.E.; Karalova, E.M.; Abroian, D.O.; Tarantul, V.Z.; Gazarian, K.G.

Molekuliarnaia Genetika Mikrobiologiia i Virusologiia 1991(10): 25-28

1991

ISSN/ISBN: 0208-0613
PMID: 1661849
Document Number: 372786
Transgenic mice were obtained inheriting the human erythropoietin gene under the control of viral regulatory elements. The reliable difference in haematocrit, the content of haemoglobin and percentage of reticulocytes in peripheral blood were not revealed. The level of serum erythropoietin in transgenic mice is several fold higher than in control mice. The increased pool of erythroid cells was observed in the bone marrow of transgenic mice, especially of normoblasts (3-fold) and reticulocytes (4,5-fold).

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