Effect of light deprivation on homeostasis, life span and development of spontaneous tumors in HER-2/neu transgenic mice
Baturin, D.A.; Alimova, I.N.; Popovich, I.G.; Zabezhinskiĭ, M.A.; Semenchenko, A.V.; Iashin, A.I.; Anisimov, V.N.
Voprosy Onkologii 50(3): 332-338
2004
ISSN/ISBN: 0507-3758 PMID: 15318708 Document Number: 583678
Twenty five female HER-2/neu transgenic mice (FVB/N), aged 2 months, were surgically deprived of lighting; 30 intact transgenic mice, kept under standard conditions, were in control. Light deprivation was followed by inhibited intake of feed, decreased body mass and delayed age-associated estral disorders, as compared with control. Mean survival rate among experimental mice was higher by 13.5% than in control (p(0.001). Mean life span among the last surviving 10% of the experimental mice was longer than in control by 21,5% while maximum life span - by 21%. Although the number of tumor bearers under 7 months in the study group was twice that in control (p0.05), they had almost equalized by the end of the experiment. The number of multiple malignancies and the size of tumor and metastases to the lung increased too.