The production and characteristics of transgenic mice expressing the surface protein gene of the human hepatitis B virus

Shvemberger, I.N.; Ermilov, A.N.; Kapitskaia, M.Z.; Dvorianchikov, G.A.; Medvedeva, N.D.; Ginkul, L.B.; Tomilin, N.V.

Tsitologiia 32(3): 252-255


ISSN/ISBN: 0041-3771
PMID: 2171172
Document Number: 366688
Transgenic mice were obtained that contained a gene of human hepatitis B surface antigen (HBsAg). The integrated HBsAg DNA sequences were inherited in the normal Mendelian fashion. 6 of 25 investigated transgenic mice expressed the HBsAg. The expression was detected in the serum and within the cytoplasm of hepatocytes. Specific tissue pathology was shown in these animals, including systemic hyperplasia of lymphoid tissue and degenerative changes in the liver and kidney parenchymatous cell elements.

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