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The novel desmethyldestruxin B2, from Metarhizium anisopliae, that suppresses hepatitis B virus surface antigen production in human hepatoma cells

Chen, H.; Yeh, S.F.; Ong, G.T.; Wu, S.H.; Sun, C.M.; Chou, C.K.

Journal of Natural Products 58(4): 527-531

1995

ISSN/ISBN: 0163-3864
PMID: 7623030
Document Number: 454426
We have examined the antiviral activity of a crude extract prepared from the culture medium of the fungus Metarhizium anisopliae. Eight active destruxins were identified which showed strong suppressive effect on the production of the hepatitis B surface antigen (HBsAg) in human hepatoma Hep3B cells. One new compound, desmethyldestruxin B-2 (1), was isolated from M. anisopliae. This structure was determined based on its nmr and mass spectral data.

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