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Pathogenetic role of disorders of cholesterol metabolism in erythrocyte membranes in patients with exertion-induced angina pectoris

Kokarev, A.N.; Kardakov, I.I.; Kas'ianov, L.S.; Pesotskiĭ, A.S.

Kardiologiia 31(2): 45-47

1991

ISSN/ISBN: 0022-9040
PMID: 2041291
Document Number: 372636
A total of 90 working-age patients suffering from exercise-induced angina were examined. As the disease progressed, there was an inhibition of cholesterol esterification processes and an accumulation of dehydrocholesterol in the lipid bilayer of red blood cell membranes. The severity of coronary atherosclerosis evidenced by multi-position selective coronary angiography was found to show a significantly positive correlation with dehydrocholesterol levels and a negative correlation with the cholesterol/cholesterol ester ratio in the membranes of red blood cells. The use of finoptin in a daily dose of 320 mg in patients with exercise-induced angina diminished the magnitude of the potentially atherogenic alterations observed in cholesterol metabolism in the cell membranes.

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