Significance of changes in phospholipid condition of cell membranes in the development of tolerance to long-acting nitrates in patients with exercise-induced angina pectoris
Kokarev, A.N.; Kardakov, I.I.
Kardiologiia 30(10): 50-52
1990
ISSN/ISBN: 0022-9040 PMID: 2127063 Document Number: 358139
Sixty one patients with exercise-induced angina were examined. The development of sustac forte tolerance was found to be related to lower levels of phosphatidylserine and phosphatidylethanolamine in erythrocyte membranes. The changes in the phospholipid composition of cell membranes were demonstrated to be largely caused by the effects of prolonged nitrates themselves. Essential given to patients with exercise-induced angina who were tolerant to the nitrates elevated the levels of phosphatidylserine and phosphatidylethanolamine in the erythrocyte membranes, which was accompanied in most cases by higher exercise tolerance as evidenced by a repeated bicycle ergometric test when the same dose of sustac forte was used. This allows the authors to recommend to use essential to abolish prolonged nitrate tolerance.