Mechanisms of renin release from juxtaglomerular cells
Skøtt, O.; Salomonsson, M.; Persson, A.E.; Jensen, B.L.
Kidney International. Suppl 32: S16-S19
1991
ISSN/ISBN: 0098-6577 PMID: 1881042 Document Number: 372522
In microdissected, nonperfused afferent arterioles changes in intravascular pressure did not affect renin secretion. On the contrary, renin release from isolated afferent arterioles perfused in a free-flow system has been reported to be sensitive to simultaneous changes in luminal pressure and flow. Hence local blood flow may be involved in the baroreceptor control of renin release. If flow is sensed, the sensor is likely to be located near the endothelial cell layer, where ion channels have been shown to be influenced by variations in shear stress.