Renin release by renin-depleted rats following hypotensive haemorrhage and anesthetics
Essadki, A.; Atkinson, J.
Pflugers Archiv European Journal of Physiology 392(1): 46-50
1981
ISSN/ISBN: 0031-6768 PMID: 7033921 Document Number: 169773
Renin-depletion, described as a decrease in renal cortex and plasma renin levels, was produced by clipping 1 renal artery of a rat and leaving the contralateral kidney in place (2 kidney 1 clip hypertension). One month later the clipped kidney was removed and after 24 h recovery such rats were renin depleted: renal cortex and plasma renin levels were 8 and 63% of normal respectively. Such renin depleted rats were incapable of releasing renin (as judged by increase in plasma renin level) in response to severely hypotensive hemorrhage and had very blunted renin release responses to pentobarbital and urethane anesthesia (59 and 17% of normal, respectively). A low renal renin status is associated with low basal and stimulated renin release. The renin depleted rat may be a useful model for the study of the role of the renin angiotensin system in phenomena such as blood pressure compensation following hypotensive hemorrhage and drinking induced by .beta.-adrenorecptor agonists.