Use of tuftsin in experimental leprosy
Vishnevetskiĭ, F.E.; Freĭdlin, I.S.; Iushchenko, A.A.; Vishnevetskiĭ, R.F.; Anokhina, V.V.; Urliapova, N.G.; Iushin, M.I.; Eskina, I.M.
Biulleten' Eksperimental'noi Biologii i Meditsiny 112(8): 181-183
1991
ISSN/ISBN: 0365-9615 PMID: 1786385 Document Number: 371627
The effect of tuftsin was studied in vivo using CBA mice infected with M. leprae by Shepard's technique and in vitro using macrophage-like cell line P. 388 (Co-cultivated with M. leprae) and the cultivated leproma tissue. It was found out that tuftsin acted as a stimulator of M. leprae multiplication in foot-pads of mice and as a prolongator of M. leprae survival in the cells of macrophage-like cell line P .388. It is concluded that using tuftsin might be useful in view of studying different aspects of experimental leprosy.