Coagulation and fibrinolytic activity of erythrocytes in varying stages of rheumatic fever with minimal activity
Karpovich, L.G.
Gematologiia i Transfuziologiia 36(11): 12-15
1991
ISSN/ISBN: 0234-5730 PMID: 1800228 Document Number: 369321
Lowered, as compared to the normal, coagulation activity of hemolyzed and intact red blood cells was recorded in rheumatic fever patients with minimal activity of the process in the presence of hypercoagulation syndrome detectable in the plasma. This activity is low-dependent on the degree of chronic circulatory insufficiency (CCI), and has a tendency to further lowering but not rising under the effect of the treatment conducted. Aggregation activity of red blood cells in patients with CCI of 0-I degree is lowered, in those with CCI of IIA and IIB-III degree--elevated, and it is highest in patients with CCI of IIB-III degree. Fibrinolytic activity of red blood cells recorded in normal subjects is lost in all the groups of patients, regardless of the observation period, with appearance or elevation of fibrinolysis inhibitors in them. Erythrocytic hemostasis alterations detected at varying stages of the course and treatment of rheumatic fever may be conducive to the reduction or growth of overall plasma-erythrocytic coagulation potential thrombophilia.