Evaluation of the effectiveness of monotherapy in the treatment of epilepsy
Brignolio, F.; Verzè, L.; Baruchello, M.
Minerva Medica 82(12): 859-862
1991
ISSN/ISBN: 0026-4806 PMID: 1780094 Document Number: 368465
On 44 patients undergoing monotherapy, with total plasma levels of drug therapeutic range, 33 had a reduction of the frequency of seizures, while the remaining 11 were unmodified. There was 90% improvement in Primary Generalized seizures, 73% in Secondary Generalized and 62% in Partial Complex; 27% of PC, 16% of PG and 16% of SG shifted to polytherapy. Considering that monotherapy can be better managed and is less toxic, we can recommend it as first choice treatment in newcomers, as a maintenance therapy, and as treatment of choice for the gradual elimination of therapy.